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CAS No.1337967-93-7 | Fasudil diMer

Name: Fasudil diMer CAS No.1337967-93-7 MF:C23H22N4O4S2 MW:482.58 Purity:97% Package: 1g,5g,50g,100g,250g Worldwide Delivery

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Product introduction

Introduction and application of CAS No. 1337967-93-7 | Fasudil diMer

Synonyms:1,4-Bis(isoquinolin-5-ylsulfonyl)-1,4-diazepane;

FasudilHydrochlorideimpurityCdimer;

FasudilHydrochloridedimerimpurity;

5-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)sulfonyl]isoquinoline;

FasudilDimerImpurity;

FasudilHydrochlorideImpurityC;

FasudilDipolymerImpurity

Specification:

ITEMS	SPECIFICATION
CAS	1337967-93-7
MF	C23H22N4O4S2
MW	482.58
Boiling point	746.5±70.0 °C
Density	1.438±0.06 g/cm3
Acidity coefficient	4+-0.13
Storage condition	2-8°C

Overview:

Fasudil hydrochloride is a new drug with a wide range of pharmacological effects. It is a 5-isoquinoline sulfonamide derivative and has an inhibitory effect on Rho kinase. It dilates blood vessels and reduces endothelial function by increasing the activity of myosin light chain phosphatase. Cell tension can improve brain tissue microcirculation, antagonize inflammatory factors, protect nerves from apoptosis, and promote nerve regeneration. Clinical application of fasudil hydrochloride may sometimes cause an increase in alanine aminotransferase (GPT) and aspartate aminotransferase (GPT), rash, dysuria or polyuria, belching, vomiting, headache, fever, decreased level of consciousness and respiratory distress. Inhibition and other adverse reactions may be related to the impurities in it. Various intermediates and analogs of the final product during the chemical synthesis of fasudil hydrochloride may become impurities, thereby affecting product quality and pharmacological activity, and may also produce fasudil dimer impurities.

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Package: 1g,5g,50g,100g,250g